A Study by Means of the Electron Microscope of the Reaction between Tobacco Mosaic Virus and Its Antiserum
نویسنده
چکیده
From the results of numerous experiments, immunologists have inferred that when a foreign material, usually protein in nature and called an antigen, is injected into an animal, it induces the formation of substances called antibodies, which appear in the animal’s blood serum and which will react with the antigen injected (l-4). When this reaction results in the formation of a precipitate, it is called a “precipitin reaction.” It seems likely that 1 antibody molecule is able to attach itself to more than one antigen particle and, vice versa, in such a manner that a framework or “lattice” of antigen particles is formed which gives rise to an antigen-antibody precipitate (1, 3, 5). On the basis of these ideas, explanations of the various phenomena of immunity have been advanced. With the development of electron microscopes (6, 7) capable of recording the sizes, shapes, and reactions of protein molecules (8), it should be possible to observe certain of these immunological reactions directly. There are reported in the present paper the results of a preliminary study by means of the electron microscope of the reaction between tobacco mosaic virus and its antiserum. Tobacco mosaic virus was selected as the antigen because of its large size and distinctive shape. Many kinds of evidence indicate that the virus particles used in the present work are essentially cylindrical in shape and have lengths of about 280 rnp and
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تاریخ انتشار 2003